With mass production marching to 17nm CMOS technology and beyond, we are fast approaching the information resolution of the biological systems such as DNA/RNA and cellular ion channels. Electronic sensing, amplification, stimulation, data conversion and transmission can effectively realize a small proximity system with interface to the biomolecularand biological domains. On the one hand, many exciting applications can be envisioned by the never-before accessible biological and biomedical information, but on the other hand, many aspects of fundamental understanding on solid-fluid interface with bio-molecules and cells remain lacking. Conventional electrode arrays and ion-sensitive FET (ISFET) face severe challenges in reliable operations and invasiveness reduction.
In consideration of unintended molecular redox and lysing at the bioelectronicinterface, nonamperometrichigh-impedance electrodes are more applicable for reliable and least invasive operations. I will present the sensor operations of the chemoreceptive MOS (CnMOS) for monitoring ions, biomarkers, pathogen DNA/mRNA, cellular action potentials and exocytosis. The steric and molecular correlation effects on the sensing surface will cause time constants of a large range and thus require specific operational methods for reliable sensing and actuation. The design problems in previous biosensors will be identified, and I will then present two successful enzyme-free and readout-label-free sensing implementations on (1) DNA-segment recognition for fast epidemic disease diagnosis, and (2) intercellular signal monitoring of enteric neurons, each with the respective signal processing to mitigate the long-term drift issues and to enhance the tolerance to low signal-to-noise ratio. With the unparalleled resolution in space and time, high sensitivity and versatile integration, this CMOS biosensor platform is potential to enable many new product applications as well as research tools.
Edwin Chihchuan Kan received the B.S. degree from National Taiwan University, Taipei, Taiwan, in 1984, and the M.S. and Ph.D. degrees from the University of Illinois, Urbana, in 1988 and 1992, respectively, all in electrical engineering. In January 1992, he joined Dawn Technologies as a Principal CAD Engineer developing advanced electronic and optical device simulators and technology CAD framework. He was then with Stanford University, as a Research Associate from 1994 to 1997. From 1997, he was an Assistant Professor with the School of Electrical and Computer Engineering, Cornell University, Ithaca, NY, where he is now a Professor. He has spent the summers of 2000 and 2001 at IBM Microelectronics, Yorktown Heights and Fishkill, NY, in the Faculty Partner Program. In 2004 and 2005, he has been a visiting researcher at Intel Research, Santa Clara, CA, and a visiting professor at Stanford University during his sabbatical leave. His main research areas include CMOS technologies, semiconductor device physics, flash memory, CMOS biosensors, ultra‐low power radio link, and numerical methods for PDE and ODE. Dr. Kanreceived the Presidential Early Career Award for Scientists and Engineer (PECASE) in October 2000 from the White House. He also received several teaching awards from Cornell Engineering College for his CMOS and MEMS courses.